Preheat oven to 350℉. Grease a 9x5 inch loaf pan and set aside.
In a medium bowl, add the flour, baking soda, baking powder, salt, cinnamon, and pumpkin spice. Mix with a wire whisk. Set aside
In a small bowl, combine the milk and vanilla and set aside.
In the bowl of a stand-up mixer, combine the butter and both sugars until light and fluffy. Add eggs one at a time and mix until incorporated. Add the pumpkin puree and mix until just blended in. Add the flour mixture in 3 parts alternating with the milk on low speed. Stop and scrape sides of the bowl when necessary.
Pour into the loaf pan. Sprinkle the crumble topping over the batter and bake for 1 hour until a toothpick inserted into the center comes out clean. Allow to cool for 10 minutes.
Crumble Topping
Add the butter, 1/3 cup flour, and the remaining ingredients to a small bowl. Mix together with a fork. Add an additional tbsp or two of flour to the mixture until it becomes nice and crumbly. I added two extra tbsp of flour.
Notes
Adapted from Pumpkin Bread recipe from Joy of Cooking cookbook.